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E. coli is comparable to the 2011 outbreak strain within Europe

A kind of E. coli much like what caused a big outbreak in 2011 has been detected in Europe, in accordance with researchers.

Two cases of Shiga toxin-producing EnteroaggregativeE. coli (EAEC) O104:H4 were reported in holland in 2019 and 2020 and in a single food isolate from 2017. There is also an individual from Austria in 2021.

In 2011, an enormous outbreak due to STEC O104:H4 occurred in Europe, mainly Germany and France, that has been connected with sprouts grown from fenugreek seeds from Egypt. The outbreak led to a lot more than 4,000 infections and 54 deaths from 16 countries, including six cases in the usa.

Following this outbreak, just a few sporadic infections with EAEC O104:H4 were reported, most linked to happen to be Turkey or North Africa, said the analysis published in Emerging Infectious Diseases.

Both recent cases in holland involved middle-aged women with abdominal cramps and bloody diarrhea. They didn’t have recent travel. The 2019 patient consumed cooked minced beef, and the 2020 case ate beef, hamburger meat, and fruit and veggies from her very own garden.

In 2021, the Austrian Agency for Health insurance and Food Safety (AGES) obtained an example from the 10-year-old girl with hemolytic uremic syndrome (HUS). This patient also reported no recent travel, but she had consumed raw veal. Also, EAEC O104:H4 was within an example from pig meat in 2017 in holland.

Researchers said it had been surprising to retrieve an isolate from the pork product. However, it generally does not indicate that pigs certainly are a reservoir, because contamination may have comes from a food handler or contaminated feed as opposed to the pigs.

Sporadic occurrence of related E. coli

Since 2016, shiga toxin-producing E. coli isolates in holland have already been whole genome sequenced to detect clusters and outbreaks nationwide. During retrospective analysis of whole genome sequencing data, two EAEC O104:H4 cases were identified in 2019 and 2020.

Scientists compared the recently found isolates, two shiga toxin-producing EAEC O104:H4 isolates from patients in holland from 2013 and representative isolates from patients in Germany who shed the outbreak strain into 2012.

The 2020 patient isolate from holland and the pork isolate clearly clustered with the representative outbreak isolates, in accordance with researchers.

However, patient isolates from holland in 2019 and Austria in 2021 appeared more much like one another and both isolates from Dutch patients in 2013 than to those from the outbreak cluster.

Genomic analysis of several post-outbreak EAEC O104:H4 isolates suggests they’re not produced from the 2011 outbreak but share a recently available common ancestor. The analysis indicates that variants of Shiga toxin-producing EAEC O104:H4 are circulating worldwide.

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