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Food allergies could be reversed in mice by targeting the microbiome

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Although some people who have dietary allergies experience mild symptoms when subjected to triggering foods, some face potentially fatal consequences. A bacterial compound called butyrate that’s created by healthy microbiomes shows promise against allergies in tests, but it’s nasty to take orally. Today, scientists describe a far more palatable solution to deliver this compound and report that their “polymeric micelles” work against peanut allergies in mice. The procedure could someday counteract various kinds of food allergies and inflammatory diseases.

The researchers will show their results at the fall meeting of the American Chemical Society (ACS).

A few of the bacteria in the gut microbiome produce metabolites, such as for example butyrate, that foster the growth of beneficial bacteria and keep maintaining the liner of the gut. In case a person’s microbiome is unhealthy and lacks these butyrate-producing bacteria, fragments of partially digested food can leak out from the gut and produce an immune reaction that results within an allergic response.

One method to treat people that have allergies is always to supply the missing bugs in their mind orally or with a fecal transplant, but that hasn’t worked well in the clinic, in accordance with Jeffrey Hubbell, Ph.D., among the project’s principal investigators (PIs). “So we thought, we will just deliver the metaboliteslike butyratethat a wholesome microbiome produces?”

“But butyrate includes a very bad smell, like dog poop and rancid butter, looked after tastes bad, so people wouldn’t desire to swallow it,” says Shijie Cao, Ph.D., who’s presenting the outcomes at the meeting for the team, that is at the University of Chicago. And also if people could choke it down, butyrate will be digested before reaching its destination in the low gut.

To overcome these challenges, the researchers, including co-PI Cathryn Nagler, Ph.D., and Ruyi Wang, Ph.D., designed a fresh delivery system. They polymerized butanoyloxyethyl methacrylamidewhich includes a butyrate group as a side chainwith methacrylic acid or hydroxypropyl methacrylamide. The resulting polymers self-assembled into aggregates, or polymeric micelles, that tucked the butyrate side chains within their core, thus cloaking the compound’s foul smell and taste.

The researchers administered these micelles to the digestive systems of mice lacking either healthy gut bacteria or perhaps a properly functioning gut lining. After released the butyrate in the low gut, the inert polymers were eliminated in the feces. The procedure restored the gut’s protective barrier and microbiome, partly by increasing production of peptides that kill off parasites, which made room for butyrate-producing bacteria.

Most of all, dosing allergic mice with the micelles prevented a life-threatening anaphylactic response if they were subjected to peanuts. “This kind of therapy isn’t antigen specific,” Cao notes. “So theoretically, it could be broadly put on any food allergies through the modulation of gut health.”

Next up are trials in larger animals, accompanied by . If those trials succeed and the U.S. Food and Drug Administration approves the oral medication, the micelles could possibly be marketed in small packets; consumers would tear open a packet and stir the contents right into a glass of water or juice. In other use the micelles, the team is analyzing data on treating inflammatory bowel diseases with the oral therapy.

The team can be investigating administration via injection. The researchers show that method allows the micelles and their cargo to build up in lymph nodes, which are section of the disease fighting capability. They discovered that this approach works well in treating peanut allergies in mice, nonetheless it may be used to suppress immune activation locallyrather than through the entire body. For instance, injections could possibly be helpful in patients who’ve had an or who’ve a localized autoimmune and inflammatory condition, such as for example arthritis rheumatoid.



More info: Microbial metabolite butyrate-prodrug polymeric micelles promote gut health insurance and treat food allergies, ACS Fall 2022. www.acs.org/content/acs/en/mee tings/fall-2022.html

Citation: Food allergies could be reversed in mice by targeting the microbiome (2022, August 21) retrieved 22 August 2022 from https://medicalxpress.com/news/2022-08-food-allergies-reversed-mice-microbiome.html

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