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New imaging technique could increase development of eye disease treatments

New imaging technique could speed up development of eye disease treatments
First author Kari Vienola is shown with the velocity-based optoretinography optical setup. The brand new approach produced by the researchers may help accelerate the development of new treatments for retinal diseases. Credit: Ravi Jonnal, University of California, Davis

Researchers are suffering from a straightforward and fast solution to perform optoretinography, an imaging technique that measures light-induced functional activity in the eye’s retina, the network of neurons in the rear of our eyes in charge of detecting light and initiating vision. A lot more than 50% of individuals in the U.S. over age 60 are influenced by retinal diseases such as for example macular degeneration and diabetic retinopathy. These diseases affect the retina’s function with techniques that reduce eyesight and will progress to blindness or even treated. The brand new approach may help accelerate the development of new treatments for eye diseases.

“Optoretinography has typically used too costly equipment that required multiple experts to use while also producing enormous data volumes requiring extensive computational resources,” said research team leader Ravi Jonnal from the University of California, Davis. “We devised a method to take action more cheaply and quickly.”

Jonnal and colleagues report their new approach, that they call velocity-based optoretinography, in Optica. In addition they demonstrate the method’s capability to measure retinal response in three healthy subjects.

“Although velocity-based optoretinography may potentially provide clinicians with an increase of accurate and earlier information regarding functional losses in the retina, its first proper impact is more prone to maintain expediting for new treatments of ,” said Jonnal, who performed a few of the first optoretinography measurements as a doctoral student in Don Miller’s lab at Indiana University. “If we are able to detect whether retinal function gets better or worse faster than with traditional tests such as for example eye charts, it’ll greatly accelerate the development of treatments.”

Tracking shape changes

Optoretinography detects slight changes in the form of neurons that generate or conduct signals in the retina. As yet, Jonnal along with other investigators purchased adaptive optics and (OCT) to visualize and track these neurons in the living, moving eye and applied motion correction algorithms to stabilize the images and extract the functional response. This costly and time-consuming process requires resolving and tracking the positioning of individual cellular features and using those positions to find out if the cell changed shape.

“Whenever we use among our systems to create optoretinography measurements, the experiment can simply take half of a day and create a terabyte of data that should be processed,” said Jonnal. “Processing the info to extract an operating signal takes, minimally, a later date or two.”

In order to avoid the necessity to resolve and track individual neurons, Jonnal and colleagues wished to see should they could instead gauge the speed, or velocity, of which the retinal neurons move in accordance with one another. “We believed that even though the positions of the features change from cell to cell, the speed of which they move in accordance with one another will be highly correlated among cells,” said Jonnal. “This became correct.”

New imaging technique could speed up development of eye disease treatments
Researchers developed a straightforward and fast solution to perform optoretinography that measures the speed, or velocity, of which the retinal neurons move in accordance with one another. The grayscale image is really a cross-section of a full time income human retina close to the fovea, acquired utilizing a custom optical coherence tomography camera. The pseudocolor overlay shows the phase velocity of the tissue. Analysis of the photoreceptor phase velocity reveals these cells contract and expand within twenty milliseconds of the onset of an obvious stimulus flash. Credit: Ravi Jonnal, University of California, Davis

Measuring moving neurons

To handle velocity-based optoretinography, the researchers developed a fresh OCT camera which allows an individual operator to assemble images from more locations in the retina than can be done with other methods to optoretinography.

The researchers demonstrated their new technique by it to get measurements from three healthy volunteers. These were in a position to acquire data from each patient in only ten minutes and also have that data processed and results available within 2-3 minutes. They showed that the functional optoretinographic responses measured with the easy approach scaled with the light stimulus dose used and that the dose-stimulus response was reproducible within and on the list of volunteers.

They’re now planning experiments targeted at demonstrating the technique’s sensitivity to disease-related dysfunction. Jonnal can be dealing with clinicians at the University of California, Davis to utilize it for patient imaging also to assist in interpreting results for trials of stem cell therapies and gene therapy treatments for inherited retinal diseases. The researchers would also prefer to apply the brand new optoretinography method of animal types of retinal disease.



More info: Kari Vienola et al, Velocity-based optoretinography for clinical applications, Optica (2022). DOI: 10.1364/OPTICA.460835

Citation: New imaging technique could increase development of eye disease treatments (2022, September 22) retrieved 22 September 2022 from https://medicalxpress.com/news/2022-09-imaging-technique-eye-disease-treatments.html

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