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Replicating mangosteen peel extract as cure for intestinal inflammation in humans and animals

Associate Professor Dr. Suthasinee Poonyachoti of the Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Thailand, has prevailed in creating a substance that replicates the chemical structure of mangosteen peel extract and that helps stall leakage in the intestine. Apart from its , the extract reduces the necessity for medication for both humans and animals.

Xanthonesa natural substance in the mangosteen peel rich with benefits

Research on mangosteen peel enabled Associate Professor Dr. Suthasinee to find xanthones, a substance in the flavanol group that’s effective in combatting or halting numerous kinds of inflammation with anti-cancer, anti-bacterial, anti-allergy, anti-inflammatory, anti-microbial, anti-malarial and anti-oxidant qualities.

To research xanthones’ capability to reduce inflammation and destroy bacteria, a study project in collaboration with the Faculty of Medicine, Srinakharinwirot University, Thailand, premiered. The project aims to build up and extract xanthones by means of hydroxyxanthones or HDX with the best efficacy for the sake of humans and animals.

“Extractions of mangosteen peels have caused a number of substances both beneficial and harmful. Moreover, they need to go through a fairly complicated process and we can not control the standard of the extracts because it depends upon factors such as for example planting methods, usage of fertilizer, climate, and care,” Associate Professor Dr. Suthasinee explained.

“We find the approach to analysis and sought to mimic the chemical structure of xanthones from mangosteen peels, giving us the required essential extracts which are simpler to apply directly within adjuvants in medicines, foods, along with other products also to control their efficacy in the very best manner possible.”

Leaky gut syndromea reason behind disease in both humans and animals

Leaky gut syndrome can result in many diseases, especially septicemia which can be hidden in . This happens if you find an abnormality in the functions of the intestines and the microvilli.

“When you can imagine the way the cells in the microvilli workthey fall into line close to one another and are in charge of screening and controlling , and bacteria that enter the bloodstream. When inflammation occurs, the cells cannot fall into line close to one another and function just like a fortress, that makes it easy for toxic or foreign substances to enter the bloodstream. The problem is dangerous and should be treated before it really is too late,” she explained.

A will not always show any observeable symptoms or if it can it might affect other physical ailments such as for example overtiredness, fatigue, headaches, or other body aches without the clear indication of the complexities.

“The reason isn’t clear but hypothesized to function as consequence of stress. If the symptom occurs in humans, they are able to consult physicians immediately. However, if this occurs in animals, it really is harder to inform if they’re sick.”

Developing HDX into health products for humans and animals

This research reaches the experimental stage to look for the quality of HDX’s performance. It’s been found in pig farms first before being experimented on humans and larger and much more diverse forms of animals. As Associate Professor Dr. Suthasinee concluded, “Later on, HDX will experiment in adjuvants in a number of products like medicines and to boost the standard of life of both humans and animals.”

The study was published in the Journal of Functional Foods.

More info: Wannaporn Chayalak et al, Hydroxyxanthone ameliorates IL1-induced epithelial barrier disruption in colonic-like cells by down-regulation of p-MLC expression, Journal of Functional Foods (2021). DOI: 10.1016/j.jff.2021.104814

Citation: Replicating mangosteen peel extract as cure for intestinal inflammation in humans and animals (2022, September 5) retrieved 5 September 2022 from

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