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Singaporean hospitals setup severe asthma registry to boost outcomes

A multi-centre, large-scale registry of severe asthma patients has been create in Singapore.

An initial of its kind in the united kingdom, the Singapore Severe Asthma Registry (SSAR) was established by way of a research network comprising Nanyang Technological University Singapore, the Lee Kong Chian School of Medicine, and three hospitals under SingHealth: Changi General Hospital, Singapore General Hospital, and Tan Tock Seng Hospital.


In accordance with a news release, the SSAR seeks to boost the knowledge of severe asthma, collect proof treatment effectiveness and safety, and identify predictors of treatment success. Up to now, it has collected data from 139 severe asthma patients having an try to register 200 patients more by yearend. It has collected anonymised data, including demography, health background, exacerbation history, treatment solution, and biomarkers such as for example lung spirometry test outcomes, full blood count along with other clinical parameters.

It is stated that the real-world evidence gathered out of this registry could inform policy decision-making and guideline implementation.

The SSAR will undoubtedly be managed by The Academic Respiratory Initiative for Pulmonary Health (TARIPH), a study network led by NTU’s LKCMedicine. The organisation will tap on SSAR data to handle research questions around severe asthma, especially about treatment plans. It will focus its research on determining the predictors of treatment success, outcomes of personalised therapies, the usage of biologics for treatment, and studying undiagnosed severe asthma in primary care.

Furthermore, the SSAR has been from the International Severe Asthma Registry (ISAR), a worldwide partnership of researchers from 26 countries. It has national registries sharing their data for research in focusing on how severe asthma affects patients differently in a variety of geographical populations. When you are section of ISAR, TARIPH can access data from other countries to compare patient characteristics and responses to treatment in Singapore with patients abroad.


In Singapore, one in five children and at the very least 5% of the populace have asthma with severe cases affecting one in 20 asthmatic individuals. Generally, this problem contributes $1.5 billion in economic burden to the united states.

As patients with severe asthma experience higher treatment burden and also have different clinical trajectories, “[t]he formation of SSAR can not only enable us to get improved ways to deliver more personalised, targeted, and effective treatment plans for patients, but we shall also better understand the responsibility of severe asthma in Singapore and introduce interventions to handle issues at a systemic level,” said Associate Professor Mariko Koh, a senior consultant at SGH’s Department of Respiratory and Critical Care Medicine, who also chairs the SSAR workgroup within TARIPH.

“The [SSAR] will go quite a distance towards identifying asthma patients that are at risky, and providing us with deeper insights from bench to bedside in improving the care and management of the patients,” added Assoc. Prof. John Arputhan Abisheganaden, TARIPH co-chair and head consultant at TTSH’s Department of Respiratory and Critical Care Medicine.

Through SSAR, researchers may also be in a position to compare data of Asian patients with non-Asian patients from other countries. In accordance with Assoc. Prof. Sanjay H. Chotirmall, TARIPH co-chair and LKCMedicine assistant dean, current guidelines for severe asthma treatment have already been produced from evidence mostly via non-Asian patients.

“There’s emerging evidence from the selection of lung diseases that Asian and non-Asian patients respond differently to treatment and also have lung diseases that behave differently,” he said, adding that is likely because of genetic differences, environmental exposures, health-seeking behaviours, and practices in health systems.

Meanwhile, Assoc. Prof. Chotirmall also noted the benefit of joining the ISAR, saying that “being section of a global registry gives us rich data where to boost outcomes for Singaporeans with severe asthma”.

“With data from 12,772 patients from 26 countries, ISAR has offered real-life findings and insights that clinical trials have missed. By joining ISAR, SSAR will enter a mutually beneficial relationship where it could increase and reap the benefits of ISARs research,” claimed Prof. David Price, director of the Observational and Pragmatic Research Institute in Singapore, an institute which also supports the ISAR.


Latest data science initiatives around Asia-Pacific add a long-term study in New Zealand that’s tracking anonymised data from over 550,000 visitors to determine the impact of multiple morbidities on the chance of hospitalisation or death from cardiovascular diseases.

Another project is creating a registry of senior Australians to create a complete picture of the ageing pathway to comprehend emerging issues and research on major but still unknown residential aged care impacts.


“As our public hospitals are more involved with improving the populace health of Singaporeans, new insights gathered out of this collaboration will undoubtedly be useful in managing patients with severe asthma locally. Registry data of the prevalent disease can help enhance detection and personalise effective asthma treatments to improve the standard of life of individuals with severe asthma,” Augustine Tee, deputy chairman of the CGH Medical Board, commented.

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