Telomeres, DNA sequences by the end of chromosomes that shorten as cells replicate and age, will not always correlate with chronological age, and there’s evidence to suggest telomere shortening could be modifiable by lifestyle factors.
The factors which are strongly connected with accelerated telomere shortening and dysfunction are oxidative stress and inflammation, explained scientists from Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences inNutrients.
The power of omega3 essential fatty acids to lessen these unwanted effects is related not merely with their welldocumented beneficial influence on numerous lifestyle diseases but additionally with their beneficial effects on telomere biology.
The usage of omega3 essential fatty acids to lessen accelerated telomere attrition and, consequently, counteract premature aging and decrease the threat of agerelated diseases raises high hopes.
The aging and lifespan of normal, healthy cells are from the so-called telomerase shortening mechanism, which limits cells to a set amount of divisions. During cell replication, the telomeres function by ensuring the cell’s chromosomes usually do not fuse with one another or rearrange, that may result in cancer.
Elizabeth Blackburn, a telomere pioneer at the University of California SAN FRANCISCO BAY AREA, likened telomeres to the ends of shoelaces, without that your lace would unravel.
With each replication the telomeres shorten, so when the telomeres are totally consumed, the cells are destroyed (apoptosis). Telomere shortening or attrition was listed among the nine hallmarks of aging in a seminal paper published in Cell in 2013 by Carlos Lpez-Otn et al.
One factor inversely linked to telomere length is chronic stress, both through the prenatal period and childhood, in addition to in adult life, wrote the Poland-based scientists in Nutrients. Depression, smoking, obesity, and alcohol consumption also accelerate telomere attrition.
Interestingly, dietary restriction and increasing dietary antioxidants drive back telomere shortening. In this context, omega3 essential fatty acids are essential dietary compounds that, because of their biochemical properties, may affect the biology of telomeres.
Their new overview of the scientific literature included seven observational (non-interventional) studies, which indicated that, generally, omega-3 essential fatty acids may are likely involved in telomere biology. Such results, however, merely show correlation rather than causation, which includes led researchers to execute randomized dietary studies using omega-3 supplements.
The Poland-based researchers reported four such intervention studies, that have been performed in a variety of populations, including mothers and their infants, people who have chronic renal impairment, the elderly experiencing mild cognitive impairment, and healthy, overweight, middleaged and seniors. Doses used ranged from just over one gram each day to four grams each day of omega-3 essential fatty acids.
The info from the randomized trials were a mixed bag, with some indicating a potential benefit among others finding no effects.
The reviewers also searched the scientific literature for data from animal studies, and found three studies that showed good results from omega-3 supplementation of the dietary plan.
As the outcomes of the presented crosssectional and randomized human and rodent studies aren’t entirely consistent, the overwhelming amount of them have demonstrated the beneficial ramifications of omega3 essential fatty acids on telomere length, wrote the reviewers.
Limitations and whats next?
Regardless of the evidence being generally supportive of a job for omega-3 essential fatty acids to safeguard against telomere attrition, the reviewers noted that sample sizes from some studies were small, while also noting that telomere length in leukocytes, that is the primary measurement found in the studies, could be dissimilar to telomere length in other tissues.
discrepancies in the presented results still indicate the necessity for a careful evaluation of the sort of omega3 essential fatty acids, their origin, dose and the timing of administration, in addition to age, gender, regional and ethnic diversity, and health status, concluded the reviewers.