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Young-onset type 2 diabetes associated with substantially higher threat of coronary disease and death, finds study

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Women and men who are identified as having type 2 diabetes (T2D) aged 40 or younger are more more likely to develop coronary disease (CVD) and die prematurely than those under 40 in the overall population, in accordance with new research to be presented as of this year’s European Association for the analysis of Diabetes (EASD) Annual Meeting in Stockholm, Sweden (19-23 Sept).

The nationwide study, comparing over 634,000 people newly identified as having type 2 diabetes with over 1.2 million matched controls over typically 6 years, indicates that folks with early-onset diabetes (aged 40 or younger) were five times more prone to develop cardiovascular disease, seven times more prone to be hospitalized with heart failure, and at the very least five times as more likely to die from CVD or from any cause weighed against their diabetes-free counterparts.

“Our findings clearly highlight the serious health implications of developing type 2 diabetes at a age and the significance of efforts to avoid diabetes in early life,” says lead author Dr. Da Hea Seo from Inha University School of Medicine, South Korea.

T2D may be the most common type of diabetes and usually occurs in middle-aged and the elderly. However, onset in adults is becoming more prevalent globally and is normally a far more aggressive form leading to earlier development of complications and higher rates of hospitalizations. As CVD is really a major reason behind death, it is very important ascertain its burden in people who have early-onset type 2 diabetes, also to measure the age of which the chance of CVD begins to improve.

For more information, researchers investigated the partnership between age at diagnosis with T2D and CVD complications and death in 634,350 people with T2D (average age at diagnosis 56 years) from the Korean National MEDICAL HEALTH INSURANCE Service (NHIS) database between 2012 and 2014, in comparison to 1,268,700 gender-, age- and CVD-history matched controls from the overall population. In South Korea, the NHIS provides mandatory medical health insurance covering almost all forms of healthcare for several Korean citizens.

Participants were followed for CVD outcomes (death from any cause, death from CVD, cardiovascular system disease, , stroke, hospitalization for heart failure) or until 2019. The researchers adjusted for a variety of factors which could influence the outcomes including age, sex, and previous history of CVD including coronary attack, unstable angina, heart failure, stroke and peripheral artery disease.

Over typically 6 years of follow-up, 172,120 (40%) of individuals with early-onset T2D and 151,363 (23%) controls had the coronary attack, or died from CVD.

The researchers discovered that threat of CVD complications was strongly associated with age and adults identified as having T2D aged 40 or younger had the best relative risk for some complications weighed against the overall population.

All risks reduced progressively with each increasing decade at age of diabetes diagnosis, but remained statistically significant. For example, individuals identified as having T2D at age 91 years or older, were around 3 x as more likely to develop cardiovascular disease and become hospitalized with heart failure than those of exactly the same generation in the overall population, and were 24% more prone to die from any cause and 25% more prone to die from CVD.

“In this large, population-based cohort study, being younger during T2D diagnosis was of a higher relative threat of death and complications in comparison to those in exactly the same group without diabetes,” says co-author Dr. Seong Bin Hong from Inha University School of Medicine, South Korea.

“Looking after teenagers with diabetes, which includes traditionally centered on type 1 diabetes, should place more focus on . Also, effective health-care policies around screening, early diagnosis and treatment will combat the near future rise of coronary disease in this increasingly common young-onset, high-risk population.”

The authors explain that although their study was large, it had been observational; they can not rule out the chance that other unmeasured factors and uncontrolled confounding factors could have affected the outcomes. They also remember that the study is bound by way of a relatively short follow-up and its own usage of a dataset from South Korea, limiting the generalizability to other populations.

Citation: Young-onset type 2 diabetes associated with substantially higher threat of coronary disease and death, finds study (2022, September 6) retrieved 6 September 2022 from

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